AMONG-POPULATION VARIATION IN MICROBIAL COMMUNITY STRUCTURE IN THE FLORAL NECTAR OF THE BEE-POLLINATED FOREST HERB PULMONARIA OFFICINALIS L.

Among-population variation in microbial community structure in the floral nectar of the bee-pollinated forest herb Pulmonaria officinalis L.

BackgroundMicrobial communities in floral nectar have been shown to be characterized by low levels of species diversity, yet little is known about among-plant population variation in microbial community composition.Methodology/principal findingsWe investigated the microbial community structure (yeasts and bacteria) in floral nectar of ten fragmente

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N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.

N6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions.RNA m6A modification is regulated by two groups of cellular proteins, writers and enchanted wonderstruck perfume erasers that add or remove m6A, respectively.HIV-1 RNA contains m6A modifications that modulate viral infecti

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Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19: Study Protocol for a Retrospective Observational Multicenter Study (SELECT)

BackgroundIn hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely.Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails.In critically ill patients, high-dose corticosteroids are often administered as salvag

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